《自然》：科学家发现，抗HIV药物或能改善记忆( 三 ) _hiv

此外，这项研究还引出了一个有趣的问题：在正常情景记忆形成的过程中，为什么人类需要在神经元上延迟高表达CCR5基因来阻断自己的记忆链接呢？
对此，一个可能的解释是，如果我们总是能清晰的记住生命中发生的每一件事情，那么生活将无法继续。CCR5或许就是大脑用来过滤掉不重要事情的细节过滤器，从而让我们去链接更有意义的记忆和体验，更好地活在当下吧。

文章插图

参考文献：
[1] Shen, Y. J. et al. CCR5 closes the temporal window for memory linking. Nature (2022)
[2] Cai, D. J. et al. A shared neural ensemble links distinct contextual memories encoded close in time. Nature 534, 115–118 (2016).
[3] Rashid, A. J. et al. Competition between engrams influences fear memory formation and recall. Science 353, 383–387 (2016).
[4] Jung, W. & Lee, S. H. Memory deficit in patients with schizophrenia and posttraumatic
stress disorder: relational vs item-specific memory. Neuropsychiatr. Dis. Treat. 12, 1157–1166 (2016).
[5] Avery, S. N. et al. Impaired relational memory in the early stage of psychosis. Schizophr. Res. 212, 113–120 (2019).
[6] Shen, W. et al. Activation of the chemotactic peptide receptor FPRL1 in monocytes phosphorylates the chemokine receptor CCR5 and attenuates cell responses to selected chemokines. Biochem. Biophys. Res. Commun. 272, 276–283 (2000).
[7] Shepherd, A. J., Loo, L. & Mohapatra, D. P. Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure. PLoS ONE 8, e76698 (2013).
[8] Joy MT. Et.al. CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury. Cell. 176(5):1143-1157 (2019)
[9] Zhou W. et.al. CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory. Elife. 5:e20985. (2016).